MDR in TB is defined as resistance to which of the following drugs?

The correct option is: Rifampicin, Isoniazid

Explanation:

• MDR-TB (Multidrug-Resistant Tuberculosis) is defined as resistance to at least two first-line anti-TB drugs: Rifampicin and Isoniazid.
• These two drugs are the cornerstone of standard treatment for tuberculosis. If the bacteria are resistant to both, it is considered MDR-TB.
• Resistance to Streptomycin alone does not define MDR-TB, although it can contribute to resistance in cases of XDR-TB (Extensively Drug-Resistant Tuberculosis), where additional drugs like Fluoroquinolones and Injectables are also resistant.

Additional Information:

• MDR-TB is a serious global health concern and requires longer, more complex treatment regimens, often involving second-line drugs that are more expensive and less effective.
• The World Health Organization (WHO) recommends that anyone diagnosed with MDR-TB undergo appropriate testing to ensure the best possible treatment options.