Which of the following is a potent vasodilator?

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  1. Noradrenaline
  2. Histamine
  3. Cimetidine
  4. Ranitidine

Answer (Detailed Solution Below)

Option 2 : Histamine
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Detailed Solution

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The correct answer is Histamine.

Key Points

  • Histamine is a potent vasodilator that plays a significant role in the immune response.
  • It is released by mast cells and basophils during allergic reactions and inflammation.
  • Histamine causes the dilation of blood vessels, which increases blood flow to affected tissues.
  • This vasodilation results in symptoms such as redness, swelling, and warmth in the area of inflammation.
  • Histamine also increases the permeability of blood vessels, allowing immune cells to access the site of infection or injury.

Additional Information

  • Noradrenaline:
    • Noradrenaline, also known as norepinephrine, is a neurotransmitter and hormone involved in the body's stress response.
    • It primarily acts as a vasoconstrictor, narrowing blood vessels and increasing blood pressure.
    • Noradrenaline is released from the adrenal medulla and sympathetic nerve endings.
  • Cimetidine:
    • Cimetidine is an H2 receptor antagonist used to reduce stomach acid production.
    • It is commonly used to treat conditions such as peptic ulcers and gastroesophageal reflux disease (GERD).
  • Ranitidine:
    • Ranitidine is another H2 receptor antagonist that decreases stomach acid production.
    • It is used to manage and treat peptic ulcers, GERD, and Zollinger-Ellison syndrome.
  • Vasodilation:
    • Vasodilation is the widening of blood vessels, which decreases blood pressure.
    • This process is essential for regulating blood flow and ensuring adequate oxygen and nutrient delivery to tissues.
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