Negatively charged DNA is wrapped around histone octamer to form:

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AIIMS BSc NURSING 2023 Memory-Based Paper
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  1. Chromosomes 
  2. Nucleosome 
  3. Chromatin
  4. Nucleoid

Answer (Detailed Solution Below)

Option 2 : Nucleosome 
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AIIMS BSc NURSING 2024 Memory-Based Paper
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The correct answer is Nucleosome 

Explanation:

  • The nucleosome, a section of DNA wrapped around a core of proteins, is the fundamental subunit of chromatin.
  • Each nucleosome is comprised of a little less than two turns of DNA wrapped around a set of eight proteins called histones, which are known as a histone octamer. 
  • The negatively charged DNA is wrapped around the positively charged histone octamer (protein) to form a structure called a nucleosome.
  • Each nucleosome is comprised of a little less than two turns of DNA wrapped around a set of eight proteins called histones, which are known as histone octamer. 
  • Each histone octamer is composed of two copies of each of the histone proteins H2A, H2B, H3, and H4. 
  • A typical nucleosome contains 200 bp of DNA helix.
  • Nucleosomes constitute the repeating unit of a structure in the nucleus called chromatin, threadlike stained (coloured) bodies seen in the nucleus.
  • The nucleosomes in chromatin are seen as ‘beads-on-string’ structures when viewed under an electron microscope (EM).

F1 Hemant Agarwal Anil 12.03.21 D5

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